Harvard*** Petri Dish Reveals Why Aging Causes Fat To Stick To Belly, Thighs, And Underarms
References:

[] Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008;134(6):933–944. doi:10.1016/j.cell.2008.07.048

[] Cruz MM, et al. Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes. Lipids Health Dis. 2018 Mar 20;17(1):55. https://www.ncbi.nlm.nih.gov/pubmed/29554895

[] Yang ZH, Miyahara H, Hatanaka A. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids Health Dis. 2011;10:120. Published 2011 Jul 21. doi:10.1186/1476-511X-10-120

[] Stefan N, Kantartzis K, Celebi N, et al. Circulating palmitoleate strongly and independently predicts insulin sensitivity in humans. Diabetes Care. 2009;33(2):405–407. doi:10.2337/dc09-0544

[] de Souza CO, Teixeira AAS, Biondo LA, Lima Junior EA, Batatinha HAP, Rosa Neto JC. Palmitoleic Acid Improves Metabolic Functions in Fatty Liver by PPARα-Dependent AMPK Activation. J Cell Physiol. 2017 Aug;232(8):2168-2177

[] Cruz MM, et al. Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes. Lipids Health Dis. 2018 Mar 20;17(1):55. https://www.ncbi.nlm.nih.gov/pubmed/29554895

[] Yang ZH, Miyahara H, Hatanaka A. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids Health Dis. 2011;10:120. https://www.ncbi.nlm.nih.gov/pubmed/21774832

[] Bolsoni-Lopes A, et al. Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation. Lipids Health Dis. 2014;13:199. https://www.ncbi.nlm.nih.gov/pubmed/25528561

[] Duckett SK, Volpi-Lagreca G, Alende M, Long NM. Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep. Diabetes Metab Syndr Obes. 2014;7:553-63. https://www.ncbi.nlm.nih.gov/pubmed/25429233

[] K. Maedler et al., “Distinct Effects of Saturated and Monounsaturated Fatty Acids on -Cell Turnover and Function,” Diabetes 50, no. 1 (January 1, 2001): 69–76, https://doi.org/10.2337/diabetes.50.1.69.

[] Nunes EA, Rafacho A. Implications of Palmitoleic Acid (Palmitoleate) On Glucose Homeostasis, Insulin Resistance and Diabetes. Curr Drug Targets. 2017;18(6):619-628. https://www.ncbi.nlm.nih.gov/pubmed/26648072

[] Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008;134(6):933–944. doi:10.1016/j.cell.2008.07.048

[] Saltiel AR, Olefsky JM. Inflammatory mechanisms linking obesity and metabolic disease. J Clin Invest. 2017;127(1):1-4 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5199709/

[] https://patents.google.com/patent/US8889739 Mozaffarian D, Cao H, Hotamisligil G, Inventors; President and Fellows of Harvard College, Cambridge, MA, assignee. Use of trans-palmitoleate in identifying and treating metabolic disease. US 8889739 B2

[] Bolsoni-Lopes A, et al. Palmitoleic acid (n-7) increases white adipocyte lipolysis and lipase content in a PPARα-dependent manner. Am J Physiol Endocrinol Metab. 2013;305(9):E1093-102. https://www.ncbi.nlm.nih.gov/pubmed/24022867

[] Cruz MM, et al. Palmitoleic acid (16:1n7) increases oxygen consumption, fatty acid oxidation and ATP content in white adipocytes. Lipids Health Dis. 2018 Mar 20;17(1):55. https://www.ncbi.nlm.nih.gov/pubmed/29554895

[] Duckett SK, Volpi-Lagreca G, Alende M, Long NM. Palmitoleic acid reduces intramuscular lipid and restores insulin sensitivity in obese sheep. Diabetes Metab Syndr Obes. 2014;7:553-63. https://www.ncbi.nlm.nih.gov/pubmed/25429233

[] Nunes EA, Rafacho A. Implications of Palmitoleic Acid (Palmitoleate) On Glucose Homeostasis, Insulin Resistance and Diabetes. Curr Drug Targets. 2017;18(6):619-628. https://www.ncbi.nlm.nih.gov/pubmed/26648072

[] Yang ZH, Miyahara H, Hatanaka A. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids Health Dis. 2011;10:120. https://www.ncbi.nlm.nih.gov/pubmed/21774832

[] Bolsoni-Lopes A, et al. Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation. Lipids Health Dis. 2014;13:199. https://www.ncbi.nlm.nih.gov/pubmed/25528561

[] de Souza CO, Vannice GK, Rosa Neto JC, Calder PC. Is Palmitoleic Acid a Plausible Nonpharmacological Strategy to Prevent or Control Chronic Metabolic and Inflammatory Disorders? Mol Nutr Food Res. 2018;62(1). https://www.ncbi.nlm.nih.gov/pubmed/28980402

[] Çimen I, et al. Prevention of atherosclerosis by bioactive palmitoleate through suppression of organelle stress and inflammasome activation. Sci Transl Med. 2016;8(358):358ra126 https://www.ncbi.nlm.nih.gov/pubmed/27683551

[] Bernstein AM, Roizen MF, Martinez L. Purified palmitoleic acid for thereduction of high-sensitivity C-reactive protein and serum lipids: adouble-blinded, randomized, placebo controlled study. J Clin Lipidol. 2014;8(6):612-7. https://www.ncbi.nlm.nih.gov/pubmed/25499944

[] Bueno-Hernández N, et al. Effect of Cis-palmitoleic acid supplementation on inflammation and expression ofHNF4γ, HNF4α and IL6 in patients with ulcerative colitis. Minerva Gastroenterol Dietol. 2017;63(3):257-263.https://www.ncbi.nlm.nih.gov/pubmed/28185444

[] de Souza CO, et al. Palmitoleic Acid has Stronger Anti-Inflammatory Potential in Human Endothelial Cells Compared to Oleic and Palmitic Acids. Mol Nutr Food Res. 2018. doi: 10.1002/mnfr.201800322 https://www.ncbi.nlm.nih.gov/pubmed/30102465

[] Erkkola, R. & Yang, B. Sea buckthorn oils: Towards healthy mucous membranes. AGROFood Industry Hi-Tech , 2003;53(3). http://www.scicompdf.se/membrasin/yang_erk_2003.pdf

[] Song IB, et al. Effects of 7-MEGA(TM) 500 on Oxidative Stress, Inflammation, and Skin Regeneration in H(2)O(2)-Treated Skin Cells. Toxicol Res. 2018;34(2):103-110. https://www.ncbi.nlm.nih.gov/pubmed/29686772

[] Akamatsu H, et al. The inhibition of free radical generation by human neutrophils through the synergistic effects of metronidazole with palmitoleic acid: a possible mechanism of action of metronidazole in rosacea and acne. Arch Dermatol Res. 1990;282(7):449-54. https://www.ncbi.nlm.nih.gov/pubmed/2150301

[] Yamamoto Y, et al. Palmitoleic acid calcium salt: a lubricant and bactericidal powder from natural lipids. J Oleo Sci. 2015;64(3):283-8. https://www.ncbi.nlm.nih.gov/pubmed/25757432

[] Yoon WJ, et al. Effect of palmitoleic acid on melanogenic protein expression in murine b16 melanoma. J Oleo Sci. 2010;59(6):315-9. https://www.ncbi.nlm.nih.gov/pubmed/20484837

[] Yang B, et al. Effect of dietary supplementation with sea buckthorn (Hippophaë rhamnoides) seed and pulp oils on the fatty acid composition of skin glycerophospholipids of patients with atopic dermatitis. J Nutr Biochem. 2000 Jun;11(6):338-40. https://www.ncbi.nlm.nih.gov/pubmed/11002130

[] https://patents.google.com/patent/US8889739 Mozaffarian D, Cao H, Hotamisligil G, Inventors; President and Fellows of Harvard College, Cambridge, MA, assignee. Use of trans-palmitoleate in identifying and treating metabolic disease. US 8889739 B2

[] "Fat and Slimy" 7.30 Report, Australian Broadcasting Commission November 1995 https://www.worldofmolecules.com/foods/palmitoleic_acid.htm http://seabuckthornguru.blogspot.com/2011/12/dr-oz-recommends-sea-buckthorn-for_16.html

[] The New Miracle Berry, Pt 1. [Web log post]. Retrieved from June 10, 2019, from https://www.doctoroz.com/videos/new-miracle-berry-pt-1

[] The New Miracle Berry, Pt 1. [Web log post]. Retrieved from June 10, 2019, from https://www.doctoroz.com/videos/new-miracle-berry-pt-1

[] Cao H, Gerhold K, Mayers JR, Wiest MM, Watkins SM, Hotamisligil GS. Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism. Cell. 2008 Sep 19; 134(6): 933-944.

[] Yang ZH et al. Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats. Appetite. 2013 Jun;65:1-7.

[] Lu X et al. Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice. Am J Physiol Gastrointest Liver Physiol. 2012 Aug 1;303(3):G367-76.

[] In-Bong Song et al., “Effects of 7-MEGATM 500 on Oxidative Stress, Inflammation, and Skin Regeneration in H2O2-Treated Skin Cells,” Toxicological Research 34, no. 2 (April 2018): 103–10, https://doi.org/10.5487/TR.2018.34.2.103.

[] Nunes EA, Rafacho A. Implications of Palmitoleic Acid (Palmitoleate) On Glucose Homeostasis, Insulin Resistance and Diabetes. Curr Drug Targets. 2017;18(6):619-628. https://www.ncbi.nlm.nih.gov/pubmed/26648072

[] Yang ZH, Miyahara H, Hatanaka A. Chronic administration of palmitoleic acid reduces insulin resistance and hepatic lipid accumulation in KK-Ay Mice with genetic type 2 diabetes. Lipids Health Dis. 2011;10:120. https://www.ncbi.nlm.nih.gov/pubmed/21774832

[] Bolsoni-Lopes A, et al. Palmitoleic acid (n-7) increases white adipocytes GLUT4 content and glucose uptake in association with AMPK activation. Lipids Health Dis. 2014;13:199. https://www.ncbi.nlm.nih.gov/pubmed/25528561

[] Erkkola, R. & Yang, B. Sea buckthorn oils: Towards healthy mucous membranes. AGROFood Industry Hi-Tech , 2003;53(3). http://www.scicompdf.se/membrasin/yang_erk_2003.pdf

[] Erkkola, R. & Yang, B. Sea buckthorn oils: Towards healthy mucous membranes. AGROFood Industry HiTech , 2003;53(3). http://www.scicompdf.se/membrasin/yang_erk_2003.pdf

[] “Diet, Nutrition and the Prevention of Chronic Diseases.” World Health Organization, World Health Organization, 6 Oct. 2014, www.who.int/dietphysicalactivity/publications/trs916/en/.

[] C. Lawrence Kien, Janice Y. Bunn, and Figen Ugrasbul, “Increasing Dietary Palmitic Acid Decreases Fat Oxidation and Daily Energy Expenditure,” The American Journal of Clinical Nutrition 82, no. 2 (August 2005): 320–26, https://doi.org/10.1093/ajcn.82.2.320.

[] Nutritionals, Best Health. “The REAL Story behind Purified Omega 7 and Why This Top Doctor Says You Should Take It Every Day.” YouTube, YouTube, 9 Dec. 2013, www.youtube.com/watch?v=4K6bm1AxvgE.

[] https://www.openagrar.de/servlets/MCRFileNodeServlet/Document_derivate_00011677/EuJLipSci_116_707-715_Bruehl_manu.pdf

[] Yang ZH, Takeo J, Katayama M. Oral administration of omega-7 palmitoleic acid induces satiety and the release of appetite-related hormones in male rats. Appetite. 2013 Jun; 65: 1-7.